KPV
PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation.
Evidence sourceOriginal animal study · PMID 18061177
Studied inCultured human intestinal and immune cells; mice with DSS- or TNBS-induced colitis
DesignCell experiments and two mouse colitis models; no human regimen
Human protocolNot established from this laboratory or preclinical research
This source is preclinical. Animal or cell exposure amounts are not human doses and are not shown here.
What researchers measured
- Cellular inflammatory signaling and cytokine secretion
- KPV uptake through PepT1
- Mouse colon histology and inflammatory cytokine messenger RNA
Experimental conditions (no animal dosing shown)
- Cell experiments
- Inflammatory stimulation in cultured intestinal epithelial and immune cells, with or without KPV
- DSS colitis model
- KPV added to drinking water in mice with DSS-induced colitis
- TNBS colitis model
- KPV added to drinking water in mice with TNBS-induced colitis
The original study includes cell experiments and mouse drinking-water experiments. The listed conditions summarize the abstract, not every control or method in the full paper. No animal exposure is converted to a human amount.